Constantly outperforming industry standards by developing biosimilars with next generation technology

Xlucane is a Biosimilar candidate to Lucentis® which is mainly used for treatment of the wet form of age related macula degeneration, an eye disease that leads to impaired vision and in worst case blindness, but has also in latter time received approvals for treatment of macular oedema (swelling of the macula) caused by diabetes, macular oedema caused by occlusion (blockage) of the veins behind the retina and choroidal neovascularisation caused by pathologic myopia.

The active substance of Lucentis® is Ranibizumab, a monoclonal antibody fragment. The mode of action of Ranibizumab is to bind to the vascular endothelial growth factor A (VEGF‑A) present in the eyes of the patients. VEGF‑A stimulates growth of blood vessels which leak fluid and blood that damage the macula and cause the impaired vision. By binding to VEGF-A Ranibizumab can inhibit the growth of these blood vessels and thereby slow down the progression of the disease and improve the vision of the patients. Lucentis® currently generates annual sales of 34,5 BSEK globally.

Xlucane has been developed with Xbranes patented technology and deep know-how in protein production resulting in a very high production yield – currently 8x what a standard system in E.coli (BL21) would result in. In-vitro characterization of Xlucane compared to Lucentis® has been conducted with very good results. After optimization of the production process is finalized Xlucane will be taken to GMP production and phase III clinical trial will be initiated. Xbrane is open for partnering discussions regarding Xlucane globally or for specific markets.

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Or contact directly:

For our Controlled Release Generics
Martin Åmark
+46 76-309 37 77

For our Biosimilars
Siavash Bashiri
+46 73-434 36 19